The Genetic Association Database is an archive of human genetic association studies of complex diseases and disorders. This includes summary data extracted from published papers in peer reviewed journals on candidate gene and GWAS studies.
The goal of this database is to allow the user to rapidly identify medically relevant polymorphism from the large volume of polymorphism and mutational data, in the context of standardized nomenclature.
Study data is recorded in the context of official human gene nomenclature with additional molecular reference numbers and links. It is gene centered. That is, each record is a record of a gene or marker. If a study investigated 6 genes for a particular disorder, there will be 6 records.
Anyone may view this database and anyone may submit records. You do not have to be an author on the original study to submit a record. All submitted records will be reviewed before inclusion in the archive. Individual fields are defined here.
Comments and suggestions are very welcome, especially with regard to errors in the data found in the DB.
A recent synopsis and analysis of the diseases and positive associations in The Genetic Association Database can be found here: Zhang et al. 2010.
The initial paper describing the GAD database can be found here.
***The August 1 2011 update contains a major contribution of records of published genetic association studies compiled from PubMed by the Office of Public Health Genomics (OPHG) at the Centers for Disease Control and Prevention (CDC) in Atlanta. OPHG maintains a searchable, online knowledge base of published, population-based epidemiologic studies of human genes to support the HuGENet collaboration. For more information on the knowledge base, see: Lin BK, et al.***
For a description on features of the August 1 update click here.
Note: GAD is intended for use primarily by medical scientists and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While GAD database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.